|
|
|
|
|
|
 |
Laboratory of Dr. Andrei V. Gudkov
Department of Molecular Genetics, NE-20
Lerner Research Institute / Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195
|
Shu Liu
American Heart Association Postdoctoral Fellow
|
Elucidating the Pathogenesis of CADASIL by Understanding the Role of Notch3
Signaling in Vascular Smooth Muscle Cells
|
Jul 2006-
Jun 2008
|
 |
South Glasgow University Hospitals NHS Trust
|
Dr K W Muir
Southern General Hospital
Telephone: 0141 201 2502
Fax: 0141 201 2510
|
Ambulatory blood pressure monitoring in (CADASIL).- is blood pressure in cadasil patients abnormal when compared to controls? Do
they have a normal nocturnal dip? Is there a correlation between phonotype and
blood pressure?
|
Nov 2005-
Nov2006
|
|
|
Several hospitals in the UK
|
St Georges Hospital NHS Trust - lead centre
|
Collection of DNA resource for small vessel disease (stroke) - part of collection will be screening for cadasil
|
Aug 2005-
July 2008
|
|
Harvard Medical School - dept of cell biology |
Spyros Artavanis-Tsakonas, Ph.D.
|
Examining molecular aspects of GOM in a way that has not been addressed before web link
|
ongoing |
|
|
South Glasgow University Hospitals NHS Trust
|
Dr K W Muir
Southern General Hospital
Telephone: 0141 201 2502
Fax: 0141 201 2510
|
- Association of right to left shunts and migraine in CADASIL
- Migraine characteristics in CADASIL
- Novel neuropsychological markers of early CADASIL
-
Genotype-phenotype interactions in CADASIL, including the role of ApoE
genotype
|
ongoing
|
|
Wang Lab Research on CADASIL. University of Michigan |
Michael Wang MD PhD
|
- Investigations of proteins that interact with the CADASIL protein Notch3.
- Research on the cellular pathways
altered by mutant Notch3.
web link
| ongoing |
 |
Ludwig-Maximilians-Universität München,Klinikum Grosshadern,Neurologische Klinik, AG Neurogenetik,=Marchioninistr. 15,81377 München, Germany
|
Martin Dichgans, M.D., Prof.
|
Functional analysis and biochemical characterization of the mutant Notch3
receptor; generation of a transgenic mouse model for CADASIL
"to determine whether the CADASIL mutated N3 receptor or fragments thereof are
toxic to VSMC"
|
ongoing |
 |
|
|
|
|
 |
|
|
|
|
 |
|
|
|
|
 |
|
|
|
|
 |
|
|
|
|
 |
|
|
|
|
 |
|
|
|
|
